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Within our examine, we were in the position to substantially escalate the dose of CX-5461 past that realized in the initial-in-human analyze in sufferers with hematologic cancers. The RP2D of 475 mg/m2 on days 1, eight, and 15 of the 4-7 days cycle, was based on phototoxicity, which occurred Even with strict UV gentle avoidance protocols and insi